The successful candidate will be part of the biology team focusing on the advancement of novel Attobody-based therapeutics that are designed to target immune signaling and treat autoimmune diseases. This position requires broad technical experience in in vitro biology with a strong emphasis on immunology and an industrial mindset underpinned by critical thinking, multitasking, and the ability to propose new approaches and ideas. The candidate will design and perform in vitro and ex vivo cell-based assays to examine mechanisms of action and potency of our emerging immunology therapeutics. Key Responsibilities

Design and perform experiments with high complexity using various in vitro and ex vivo molecular and cell-based model systems/assays to support characterization of biologics against immunology targets
Design, optimize, and execute hypothesis driven experiments to test drug potency and immunological mechanisms of action.
Design and execute target validation experiments to validate multiple immunological targets and move potential targets into the pipeline
Select and manage CROs as needed for the design and execution of robust preclinical data packages to support drug discovery programs
Hands-on work will include isolation and culture of primary immune cells, propagation and modification of cell lines, and generating and utilizing cell-based assays for functional screening of biologic molecules and MOA studies
Analyze and present data, rationale, and design of in vitro studies to the project teams.
Provide experimental support and rationale for discovery and validation of new drug targets and preclinical development for existing projects in the immunology space
Work collaboratively on multiple projects concurrently and coordinate activities across functions

Basic Qualifications

PhD in Immunology/Cell Biology or other relevant discipline, preferably in autoimmune disease field
Hands-on in vitro assay development experience in immunology is required, preferably in the biotechnology or pharmaceutical industry setting
Broad knowledge and technical experience in in vitro biology with a strong focus on T cell biology and immune cell interactions
Deep understanding and extensive hands-on experience with various in vitro immunology laboratory techniques are required, including but not limited to flow cytometry, immune cell culture and immunology assays
Capable of working independently in a fast-paced, team-oriented environment, demonstrating multitasking capabilities
Excellent troubleshooting, data analysis and interpretation skills are required
Great communication skills and team spirit are a must; the ability to present results at project team meetings is required

Preferred Qualifications

Deep understanding of the pathophysiology of autoimmune diseases and the molecular signal transduction inside and outside of the immune cells
Experience of immunology target validation
Experience of designing and executing high throughput screening assays

About Attovia Attovia is creating a pipeline of biotherapeutics with initial focus immune-mediated disease. The company leverages Attobody™, a novel biologics platform, to generate small format biparatopic binders that expand the addressable target universe across disease areas and can offer stronger efficacy, faster speed to response, and an improved safety profile than traditional approaches. We are currently progressing multiple programs across immune-mediated disease indications. Our culture is centered around five core pillars:

Integrity
Learning & Growth
Drive for Excellence
Innovation
Teamwork & Collaboration We take pride in fostering a strong team and dynamic work environment, and we are seeking individuals who align with our values and contribute to a positive and impactful workplace. Attovia is located in Fremont, CA, with planned future relocation to the mid-Peninsula area in 2025. Attovia is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. Learn more about Attovia: www.attovia.com Leveling and salary is commensurate with experience. Scientist I: $129,000 - $150,000 Scientist II: $141,000 - $165,000

Attovia Therapeutics jobs

Scientist I/II, Biology